Duchenne Muscular Dystrophy: Accurately Predicting Loss Of Ambulation
نویسندگان
چکیده
منابع مشابه
Predicting the loss of ambulation in Duchenne muscular dystrophy.
Duchenne muscular dystrophy (DMD) is a devastating muscle disease with pre mature loss of ambulation1. The disease is caused by deficiency of the sarco lemmal protein dystrophin and results in weakness affecting the proximal portions of the limbs, usually starting during the third and fourth years of life, in association with progressive loss of functional abilities1. The unique medical treatm...
متن کاملMonitoring changes and predicting loss of ambulation in Duchenne muscular dystrophy with the Motor Function Measure.
AIM To assess changes in motor function in patients with Duchenne muscular dystrophy using the Motor Function Measure (MFM). METHOD Three studies were performed. Two studies included only physiotherapy-treated patients, with 13 patients (males mean age 11y 7mo, SD 1y 10mo, range 8-14y) in the 3-month study and 41 patients (males mean age 14y 1mo, SD 5y 5mo, range 6-32y) in the 1-year study. A...
متن کاملDuchenne muscular dystrophy An overview of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) affects approximately 1 in 3,500 live male births [1]. It is caused by a large variety of mutations in the dystrophin gene. Because of these mutations, the body can no longer make dystrophin which is a protein important for stabilisation of the muscle cell during a contraction. Without dystrophin, muscle cells are damaged and slowly replaced by fat and scar tis...
متن کاملP164: Adeno-Associated Viral Vectors in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
متن کاملDuchenne muscular dystrophy.
Progress in understanding the role of dystrophin raises promising hopes for a treatment for Duchenne muscular dystrophy. In addition, great improvements have been made in the ability to diagnose this disease using simple molecular methods.
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ژورنال
عنوان ژورنال: Paediatrics & Child Health
سال: 2010
ISSN: 1205-7088,1918-1485
DOI: 10.1093/pch/15.suppl_a.30a